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WHO pauses trial of hydroxychloroquine over safety concerns
Washington Post (05/26/20) Elfrink, Tim
The World Health Organization (WHO) on Monday announced it had temporarily halted its global trial of hydroxychloroquine, citing a new study that found a significantly higher risk of death among those taking it or the closely related drug chloroquine. "The Executive Group has implemented a…
May 25, 2020 Publication Pharmacy Today Daily Edition
Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery
NIH News Release (05/22/20)
New research indicates that remdesivir, an investigational antiviral drug made by Gilead Sciences, is superior to the standard of care for the treatment of COVID-19. The preliminary analysis, published in the New England Journal of Medicine, is based on data from the Adaptive COVID-19 Treatment…
May 25, 2020 Publication Pharmacy Today Daily Edition
Malaria drug is tied to increased risk of heart problems and death in new study
New York Times (05/22/20) Grady, Denise
Coronavirus patients taking the malaria drugs hydroxychloroquine and chloroquine saw no benefit and some were at increased risk of abnormal heart rhythms and death, according to new research. The observational study, which was published in The Lancet, is based on the records of nearly 15,000…
May 25, 2020 Publication Pharmacy Today Daily Edition
CDC estimates that 35% of coronavirus patients don't have symptoms
CNN (05/22/20) Azad, Arman
Based on real-world data, CDC estimates that 35% of people with COVID-19 are asymptomatic, that 40% of infections occur before they feel sick, and that 0.4% of patients with symptoms do not survive. The agency emphasizes that the numbers are not projections of the expected impact of the pandemic,…
May 25, 2020 Publication Pharmacy Today Daily Edition
Acella Pharmaceuticals issues voluntary nationwide recall of certain lots of thyroid tablets due to super potency
FDA Recalls, Market Withdrawals, & Safety Alerts (05/22/20)
Acella Pharmaceuticals announced a voluntary recall of 13 lots of 30-mg, 60-mg, and 90-mg thyroid tablets (NP Thyroid) after testing found the lots were super potent, containing up to 115% of the labeled amount of liothyronine (T3). Patients being treated for underactive thyroid who take…
May 25, 2020 Publication Pharmacy Today Daily Edition
Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19
New England Journal of Medicine (05/21/20) Ackermann, Maximilian; Verleden, Stijn E.; Kuehnel, Mark; et al.
With partial funding from NIH, researchers studied changes in the peripheral lungs of patients who died from COVID-19, which can cause progressive respiratory failure. The study compared lungs from seven patients who succumbed to coronavirus with those of seven people who did not recover from acute…
May 25, 2020 Publication Pharmacy Today Daily Edition
Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with HFrEF
The Lancet (05/21/20) Vaduganathan, Muthiah; Claggett, Brian L.; Jhund, Pardeep S.; et al.
Researchers compared the treatment effects of comprehensive disease-modifying (DM) pharmacological therapy with that of conventional therapy in the setting of heart failure with reduced ejection fraction (HFrEF). They conducted a cross-trial analysis using data from a collective 15,880 participants…
May 25, 2020 Publication Pharmacy Today Daily Edition
More people are taking drugs for anxiety and insomnia, and doctors are worried
Wall Street Journal (05/25/20) Petersen, Andrea
An increase in prescriptions for anti-anxiety medications and sleep aids during the COVID-19 pandemic has prompted doctors to warn about the possibility of long-term addiction and abuse of the drugs. Prescriptions for anti-anxiety medications rose 10.2% in the United States to 9.7 million in March…
May 25, 2020 Publication Pharmacy Today Daily Edition
World Health Organization warns of 'second peak' in areas where coronavirus is declining
Reuters (05/25/20)
The World Health Organization (WHO) says an "immediate second peak" of COVID-19 cases could emerge in countries where infections are declining if they ease preventative measures prematurely. During an online briefing on Monday, WHO emergencies head Mike Ryan, MD, pointed out that the globe is still…
May 25, 2020 Publication Pharmacy Today Daily Edition
Hospitals are rationing remdesivir
Wall Street Journal (05/22/20) Evans, Melanie; Walker, Joseph
Gilead Sciences is donating early supplies of remdesivir to the U.S. government, which is distributing it to states. Physicians say FDA's criteria for remdesivir use under its May 1 emergency authorization are not specific, and there is little published research indicating which COVID-19 patients…
May 25, 2020 Publication Pharmacy Today Daily Edition